Mouse Morphology, Function and Genetics

Animal experiments, especially using mice and rats, are an important part of many PhD projects. A better understanding of rodent anatomy, histology, pathology, genetics, wellbeing, and a proper perspective of the difference of rodent models versus human physiology can improve the quality of these experiments substantially. Participants follow lectures in the morning and learn hands-on skills in the afternoon.

This course aims to provide a practical understanding of the anatomy, histology and pathology of what is currently the most frequently used experimental animal, the house mouse. A better insight in their (ever changing) genetic make-up can improve the quality of experiments substantially. Additionally, the students will be introduced to modern imaging and genetic modification techniques to enable active participation in the planning of studies. Finally, we want to familiarize the students with some well-known pitfalls of extrapolating findings from mice to man.

After finishing this course students:
– Can describe and demonstrate the anatomy and histology of major organs of the mouse.
– A
re able to choose mouse strains suitable for their research.
Can interpret histological and imaging data.
Can judge behavior and deduce wellbeing of experimental animals.
Can design mouse experiments that are better suited for translation to humans.

This course is organized and coordinated by the Tytgat Institute for Liver & Intestinal Research and the Department of Medical Biology, in collaboration with the OOA. If you are an OOA member, you can participate free of charge. Please indicate on the registration form that you are OOA member!

Target audience:

November 22 -26, 2021
Amsterdam UMC, AMC
PhD candidates, postdocs and technicians
1.5 EC

Dr. J.E. Seppen, Prof. dr. V.M. Christoffels
Francisca van Leeuwen-Hilbers (